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However, these studies, because of their design and low rates of observed events, were unable to show a clear effect of therapy on the risk of death from coronary heart disease or death from any cause.
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Institute of Medicine updated Estimated Average Requirements (EARs) and Recommended Dietary Allowances (RDAs) for niacin in 1998.
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Amiodarone, amlodipine, or ranolazine: Simvastatin dose should not exceed 20 mg once daily.
In addition, the change in CIMT over 2 years in the monotherapy groups treated with simvastatin was significantly less in ENHANCE (0.
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The molecular target of ezetimibe has been shown to be the sterol transporter, Niemann-Pick C1-Like 1 (NPC1L1), which is involved in the intestinal uptake of cholesterol and phytosterols.
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Ezetimibe may cause the risk of severe liver damage when administrated with statins or may cause muscles damage when taken with fibrate or statins.
Results of a clinical study that compared people who took ezetimibe and simvastatin with people who took simvastatin alone found that although the group of people taking ezetimibe and simvastatin had lower amounts of cholesterol in the blood, there was no difference between the two groups in the amount of cholesterol and fat buildup on the insides of the blood vessels in the neck.
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It should, however, be noted that 42% of patients, regardless of treatment, stopped the study drug before the end of the trial.
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