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There are case reports of success with deep brain stimulation in treating tremor in multiple sclerosis, and the FDA is currently considering the results of a National Institutes of Health (NIH)-funded trial of dual lead deep brain stimulation for Holmes tremor in multiple sclerosis.

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Patients who did not not respond to lithium are benefitted by this.

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In two of the cases the plasma levels increased following the initiation of the ER dosage form with no signs of toxicity and returned to values within therapeutic range with dosage reduction.

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One female and six male research volunteers averaging 26 1 years (mean SD) completed the 58-day experiment.

The study consisted of a 4 week baseline period followed by a 12 week experimental period (including an initial 2 week titration phase).

The increased risk of suicidal thoughts or behavior with AEDs was observed as early as one week after starting drug treatment with AEDs and persisted for the duration of treatment assessed.

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Treatment of bipolar affective disorder: new drug treatments are emerging, but more clinical evidence is required.

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