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Day two and I'm feeling a little weird but better than yesterday. I'm on 50 mg to start. I've been on Zoloft before and don't remember feeling like this. Last time I felt better almost instantly. I been off it for about 6 years. I'll stick with it this time because I know it does work.

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I have now been on this medication for 6 days and I'm seeing a terrific change not 100% yet but it's giving me light and life back again. I am loving this change I didn't think I was helpable. I thought I was too far gone but slowly am making a come back.

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The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication".

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In particular, the efficacy of l-tryptophan, a precursor of serotonin, and of pyridoxine, which serves as a cofactor in the conversion of tryptophan into serotonin, also favors serotonin deficiency as a cause of PMDD.

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Thus sertraline multiple dose pharmacokinetics appear to be unaffected by renal impairment (see PRECAUTIONS).

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