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If a patient or caregiver is not able to demonstrate that they can measure the dose and administer the product successfully, you should consider whether the patient is an appropriate candidate for self-administration of Aranesp or whether the patient would benefit from a different Aranesp presentation.

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To decrease these risks, as well as the risk of serious cardiovascular and thromboembolic reactions, use the lowest dose needed to avoid red blood cell (RBC) transfusions.

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Public Citizen estimated that through 2001 there had been 21 cases of severe liver toxicity reported with tolcapone, with eight cases resulting in death.

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Over this dose range, approximately 95% of all patients responded with a clinically significant increase in hematocrit, and by the end of approximately 2 months of therapy virtually all patients were transfusion-independent.

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Is it necessarily advised that some treatment is better than none at all?

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These persistent conditions - the nation's leading causes of death and disability - leave in their wake deaths that could have been prevented, lifelong disability, compromised quality of life, and burgeoning health care costs.

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