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I was first introduced to Atopex at the vet clinique I brought my dog to when she was suffering from dermatitis. The vet immediately prescribed Atopex after he saw the dog's sores. I was so amazed at the way Atopex cured my dog's skin! I haven't noticed any side effects or anything that could spoil the general impression of the medication. I'm absolutely satisfied with it and would recommend it to other dog owners.

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Higher-frequency topical cyclosporine would increase the residency time of medication.

Interestingly, high-dose powdered whole grapefruit has been shown to increase blood cyclosporine concentrations in dogs, possibly because grapefruit furanocoumarins inhibit intestinal P-450 3A microsomal enzymes, thus increasing oral bioavailability.

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An important subset of the cytochrome P450 family is the CYP3A4 isoenzyme, which accounts for nearly 60% of the total CYP450 in the liver and approximately 70% in the intestine.

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Once a patient is adequately controlled and appears stable the dose of cyclosporine capsules (modified) should be lowered, and the patient treated with the lowest dose that maintains an adequate response (this should not necessarily be total clearing of the patient).

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Increased risk of infection applies to all systemic immune-suppressing medications, especially when used in combinations.

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Most patients receiving CellCept were also receiving other drugs known to be associated with these complications.

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During the initial eight weeks, neither the physician responsible for evaluating the patients nor the patients knew the identity of the medications dispensed, which were identical in appearance and taste.

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