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There are case reports of success with deep brain stimulation in treating tremor in multiple sclerosis, and the FDA is currently considering the results of a National Institutes of Health (NIH)-funded trial of dual lead deep brain stimulation for Holmes tremor in multiple sclerosis.
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At that time I was being treated with Serzone.
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In two of the cases the plasma levels increased following the initiation of the ER dosage form with no signs of toxicity and returned to values within therapeutic range with dosage reduction.
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One female and six male research volunteers averaging 26 1 years (mean SD) completed the 58-day experiment.
The study consisted of a 4 week baseline period followed by a 12 week experimental period (including an initial 2 week titration phase).
The increased risk of suicidal thoughts or behavior with AEDs was observed as early as one week after starting drug treatment with AEDs and persisted for the duration of treatment assessed.
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Divalproex Sodium Delayed-Release Tablets to Divalproex Sodium Extended-Release TabletsIn adult patients and pediatric patients 10 years of age or older with epilepsy previously receiving divalproex sodium delayed-release tablets, divalproex sodium extended-release tablets should be administered once-daily using a dose 8 to 20% higher than the total daily dose of divalproex sodium delayed-release tablets (Table 1).
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The original manufacturer uses a brand name whereas a generic drug is usually called by the name of the active ingredient.
In six patients who were seropositive for HIV, the clearance of zidovudine (100 mg q8h) was decreased by 38% after administration of valproate (250 mg or 500 mg q8h); the half-life of zidovudine was unaffected.
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Treatment of bipolar affective disorder: new drug treatments are emerging, but more clinical evidence is required.
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For these patients under 2 years, valproate sodium should be used with extreme caution as a sole agent.
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