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Pittsburgh School of Medicine, Pittsburgh, PA, USA; University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.

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The efficacy and safety of aripiprazole as adjunctive therapy in major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled study.

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Efficacy for symptoms, stability, adverse effects are studied.

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Public health advisory: deaths with antipsychotics in elderly patients with behavioral disturbances.

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The presence of PVP in the spray drying solution can affect the solubilization capacity significantly, but further experimentation is required before its effect is fully understood.

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It's probably important to note that this drug shouldn't be used for anyone without mood-stabilization issues in their depression.

However, in another trial, clomipramine was not therapeutic in managing stereotypies, aggression, and hyperactivity in eight hospitalized children with autism, aged 3 to 8 years, and adverse effects were common.

Most (57%) had mild, stable, or no psychotic symptoms before aripiprazole initiation.

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For example, stimulation of postsynaptic D2 receptors may be further augmented if the dosage of the previous antipsychotic was reduced or withdrawn before initiating aripiprazole because additional receptors would be available for interaction with aripiprazole.

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The risk of extrapyramidal effects is increased in people under 20 years of age, and with high-dose or prolonged therapy.

See Boxed Warning and also see Pediatric Use under Cautions.

Efficacy was measured by the effectiveness of the response elicited by an agonist.

Children or adults who ingested acute overdoses have usually manifested central nervous system depression ranging from mild sedation to coma; serum concentrations of aripiprazole and dehydroaripiprazole in these patients were elevated by up to 3-4 fold over normal therapeutic levels, yet to date no deaths have been recorded.

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The risk for inheriting schizophrenia ranges from about 10% for those who have one first-degree family member (mother, father, sister, brother) with the disease to about 40 - 65% if the disease affects both parents or an identical twin.

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When the CYP3A4 inhibitor is withdrawn from the combination therapy, the aripiprazole dose should be increased.

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Currently available research, with an emphasis on randomized, controlled studies, demonstrates that SRIs are more efficacious in adults and older adolescents compared with children for the treatment of repetitive behaviors, and children may exhibit more behavioral activation with an SRI.

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