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Last year I have traveled to Madagascar. It is the biggest island in the Indian Ocean and the biggest island in the whole world. The flora and fauna are astonishing there, as well as the range of different bacteria and infections one can catch there. Before the trip I have taken Quinine to protect me from malaria as it is a very nasty disease to catch. I started on Quinine two days before the departure and continued for several days after I came back. I believe it's due to Quinine that I have not contracted malaria, neither have I had any side effects connected with taking the medication. It is very important that such vital drugs that help prevent life-threatening diseases do not create major difficulties for people who have no other way out but taking them.

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I've learned the warning sign of an impending leg cramp and I always keep a small supply of 200 mg quinine sulfate accessible. I use very small containers and have one in the car, one in my backpack when hiking and one in my pocket when out and about. My leg cramps are so painful that it seems that the muscle is tearing itself apart and luckily the pills are within easy reach so the tension ends within a couple of minutes.

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This causes a variety of problems, including muscle cramps.

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While normal, so-called “uncomplicated” malaria usually still makes you feel pretty bad, the symptoms tend to be quite general, such as a high fever (cycles of fever are characteristic of malaria infections, usually every 2 or 3 days), chills, nausea etc.

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Pyrimethamine-dapsone (Maloprim) is associated with agranulocytosis, especially if the recommended dose is exceeded, and should be reserved as a second-line agent for travellers to high risk areas.

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From July 1999 to February 2003, 187 patients were enrolled in five centers in Italy, of whom 93 were randomized to receive mefloquine (the M group) and 94 were randomized to receive quinine plus SP (the QSP group).

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