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Other limitations of the study include the fact that patients who died may have been sicker than those who survived; that the study can only show an association between time to treatment and the chances of survival, not that one causes the other; that there may be unknown factors that might affect the results such as the quality of chest compressions and other additional treatments; and that the researchers do not know how the introduction of standardised data assessment and systematic interactive feedback to all staff in hospitals participating in the trial might have benefitted patients in this trial compared to those treated elsewhere.

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Report any side effects with simvastatin to FDA's MedWatch program using the information at the bottom of the page in the "Contact Us" box.

The number-needed-to-treat to prevent one CV event (NNT) is about 67 for the average very-high-risk IMPROVE-IT patient with about a 15% 5-year hard CV event rate.

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Patient taking Ezetimibe along with a statin must get their blood test done on regular basis to ensure proper functioning of the liver.

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The Improved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) evaluated the effect of ezetimibe combined with simvastatin, as compared with that of simvastatin alone, in stable patients who had had an acute coronary syndrome and whose LDL cholesterol values were within guideline recommendations.

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For individuals with both diabetes and hypertension, further reduction in sodium intake should be individualized.

LDL cholesterol levels were reduced to a similar extent after 4 weeks of treatment with simvastatin and ezetimibe (15.

Benefit of Early Statin Therapy in Patients With Acute Myocardial Infarction Who Have Extremely Low Low-Density Lipoprotein Cholesterol.

The Clinical Evaluation of Remote Notification to Reduce Time to Clinical Decision (CONNECT) trial found that wireless remote monitoring with automatic clinician alerts significantly reduced the time to a clinical decision in response to clinical events as well as reduced the length of hospital stay.

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Taking Vytorin, a medicine used to lower cholesterol, during pregnancy could harm the unborn child.

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