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As with most antidepressants, what we know about their activity in pregnant women is mostly obtained from animal studies, not from large-scale studies in humans.
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OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.
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Patients should be cautioned about the risk of bleeding associated with the concomitant use of venlafaxine hydrochloride and NSAIDs, aspirin, or other drugs that affect coagulation.
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The New Zealand Medical Journal 119 (1230): U1875.
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The manufacturer recommends regular BP monitoring during treatment.
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These results provide a heuristic explanation that ties together the in vitro binding affinity of venlafaxine for the serotonin and norepinephrine uptake pumps and its dose-dependent clinical pharmacology with respect to both efficacy and tolerability.
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This article explores one of the newer classes of drugs for treating depression: serotonin-norepinephrine reuptake inhibitors (SNRIs).
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Changes in platelet 5-HT uptake and the pressor response to intravenous tyramine were assessed following the initial dose and after 1 and 2 weeks of drug administration.
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One study using an internet-based approach (mailing supplements, report results online) with a rather large sample of 1551 found Kava and placebo to be equally effective in reducing anxiety.
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This GSK supported collaborative research trial (study 826) was a prospective, multicenter, 8-week, randomized, double-blind, parallel group, forced-titration of paroxetine CR (12.
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According to the findings provided from these three RCTs, bupropion XL was as effective as venlafaxine XR for adult MDD patients.
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Since pilot-scale manufacturing facilities are not available at the FDA, this collaboration provides the Agency with an opportunity to conduct on-line research related to the implementation and validation of PAT tools.
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This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and fiber provides a lower incidence of nausea and vomiting than the conventional tablets.
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In vitro and in vivo studies indicate that venlafaxine is metabolized to its active metabolite, ODV, by CYP2D6, the isoenzyme that is responsible for the genetic polymorphism seen in the metabolism of many antidepressants.
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Key question 4: How do the efficacy, effectiveness, or harms of treatment with antidepressants for a depressive syndrome differ for the following subpopulations: elderly or very elderly patients; other demographic groups, defined by age, race or ethnicity, or sex; and patients with medical comorbid conditions, such as ischemic heart disease or cancer?
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