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The numbers represent the following sources: (1) International Agency for Research on Cancer (IARC); (2) Environmental Protection Agency lists pursuant to the Clean Air and Clean Water Acts; (3) General Industry Safety Order Section 5155; (4) California Department of Pesticide Regulation's list of Restricted Materials; (5) Information Alerts put out by the Hazard Evaluation and Information Service pursuant to Labor Code Section 147.
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While many of the connective tissues diseases have been associated with PAH, the most common etiology is that of the systemic sclerosis spectrum of disease, particularly limited systemic sclerosis.
While oral contraceptives can cause prolonged jaundice, they have not been definitely associated with vanishing bile duct syndrome or fatal liver disease.
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The higher risk of venous thromboembolism in users of oral contraceptives containing desogestrel or gestodene compared with those containing levonorgestrel is in line with several previous studies, although not all (table 4).
Current exposures to levonorgestrel and the drug of interest were replaced with a variable coded as exposure to the drug, no exposure to the drug, and exposure to levonorgestrel.
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Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation.
In accordance with the notion that suppression of SHBG is involved in the androgenic effects of danazol, the drug has synergistic rather than additive androgenic effects in combination with testosterone in bioassays (which is most likely secondary to the increased free testosterone levels).
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Shortly after market introduction, press reports and independent studies suggested side effects occurred more intensely and more commonly than shown by the manufacturer in their clinical studies.
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This limitation could introduce a bias if women experiencing a thromboembolic event while taking a combined oral contraceptive with 20 µg of oestrogen died more rapidly and before admission to hospital compared with women taking one with 30-40 µg of oestrogen, which seems unlikely.
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For the composite endpoint we used the date of the first incident.
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In group T, the main reasons for interruption of treatment were arthralgia in 5 women, hot flushes and hair loss in 2 women, decreased libido in 2 women, arthralgia and hot flushes in 1 woman, arthralgia and myalgia in 1 woman, hot flushes and depression in 1 woman, myalgia in 1 woman and depression in 1 woman.
Indian Journal of Medical Ethics 13 (1).
It is pertinent to note that 3 patients developed stress urinary incontinence (SUI) and 3 developed genital prolapse after completion of the course of therapy and were detected during follow-up at the end of 9 months.
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Each risk factor, when included individually, did not show a major effect on the results for drug exposures.
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Review of Transdermal Nonpatch Estrogen Therapy for the Management of Menopausal Symptoms.
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Since endometriosis is a chronic disease, future investigations should clarify whether the long-term administration of AIs is superior to currently available endocrine therapies in terms of improvement of pain, adverse effects and patient satisfaction.
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Information presented at medical meetings should be viewed as preliminary until published in a peerreviewed journal.
The side effects featured here are based on those most frequently appearing in user posts on the Internet.
The estimate would also be increased by the inclusion of relatively more new users or short term users of oral contraceptives, or if many women were using oral contraceptives that contained desogestrel, gestodene, or drospirenone compared with those containing levonorgestrel.
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The number 200 is the number of women approached, not the number of women enrolled.
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